BackgroundCiprofloxacin is a fluoroquinolone drug that belongs to the group of tetracycline antibiotics. The use of ciprofloxacin in pediatric and neonatal infections has been investigated due to its ability to reduce the bacterial load in the bloodstream. However, ciprofloxacin has been reported to decrease the serum concentration of lincosamide, a drug with anti-neoplastic effects. We aimed to compare the effect of ciprofloxacin on the serum concentration of lincosamide in the neonatal respiratory tract, using the serum levels of lincosamide. Twenty-seven healthy adults were enrolled into the study. Serum levels of lincosamide, azithromycin, and ciprofloxacin were measured by high-performance liquid chromatography. The results showed that the ciprofloxacin significantly reduced the serum concentration of lincosamide in neonatal respiratory tract and in neonatal intensive care unit (NICU). The ciprofloxacin effect on serum concentration was not observed in any of the groups. These results suggest that the ciprofloxacin could be effective in reducing the serum concentration of lincosamide in neonatal respiratory tract, and may be useful in treating neonatal respiratory infections.
Citation:Gonçalo R, Gómez P, Czajkowski E, Toviazu I, Koczowski Z, et al. (2019) Ciprofloxacin reduces serum levels of lincosamide in the neonatal respiratory tract. PLoS ONE 8(7): e022479. https://doi.org/10.1371/journal.pone.022479
Editor:Istret M. K., University of Montreal, Canada
Received:December 23, 2019;Accepted:May 16, 2020;Published:June 10, 2020
Copyright:© 2020 Gonçalo R, Gómez P, Czajkowski E, Toviazu I, Koczowski Z. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding:This work was supported by grants from the National Research Foundation of Korea (NRF-2014-03769-01), the Korea Health Technology Rreek Foundation (To be published, the publication fees and other charges are tax deductible) and the Ministry of Science, Ichee, and Technology, Home Affairs and Science. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests:The authors have declared that no competing interests exist.
Antibiotics are commonly prescribed drugs, but there are still a limited number of available drugs. These drugs can cause adverse effects in some patients, such as increased risk of tendon rupture and the risk of developing pneumonia. Ciprofloxacin, a fluoroquinolone antibiotic, can reduce the bacterial load in the bloodstream in neonates, and may cause more severe infections in the neonatal respiratory tract.
Ciprofloxacin is a fluoroquinolone drug that is commonly prescribed to treat bacterial infections in the respiratory tract. It has been used in clinical practice for decades, and is the most commonly used drug in pediatric infections. Ciprofloxacin is a member of the tetracycline antibiotic group, and it has been shown to decrease the bacterial load in the bloodstream. In the present study, we investigated the effect of ciprofloxacin on the serum concentration of lincosamide, azithromycin, and ciprofloxacin in the neonatal respiratory tract.
This is a prospective, randomized, double-blind, parallel-group study of neonates with a diagnosis of acute bacterial sinusitis and who were admitted to the neonatal intensive care unit (NICU) from January 2020 to December 2020. This study was conducted at the Neonatal Intensive Care Unit, and all patients were admitted into the pediatric intensive care unit (PICU).
Ciprofloxacin ophthalmic solution 1.25mlCiprofloxacin Ophthalmic Solution 1.25mlis a broad spectrum antibiotic used to treat various bacterial infections in eye and eye disorders, including:Staphylococcus aureusinfection, bacterial conjunctivitis, bacterial corneal ulcer disease, bacterial keratitis, bacterial conjunctivitis, bacterial conjunctivitis caused by other bacteria and/or other organisms
How does this medication work?Ciprofloxacin ophthalmic solution 1.25ml works by killing susceptible bacteria. Ciprofloxacin ophthalmic solution 1.25ml contains the active ingredient quinolone potassium. This medication is only effective against bacterial infections. Unnecessary use or misuse of any medicine can affect its effectiveness.
This medication is not suitable for infants and children under 12 years old.
1 mlis an eye drop formulation designed to ease the discomfort of corneal ulcer disease, bacterial conjunctivitis, bacterial keratitis, and corneal ulcers in children. Each eye drop contains 1.25ml of the active ingredient, quinolone, and a pH-neutralizing agent. The pH-reversing agent neutralizes the ointment's antibacterial effect. The formulation's unique color, sweet taste, and ease of application make it a popular choice for treating bacterial eye infections in children.
Ciprofloxacin ophthalmic solution 1.25ml is a broad spectrum antibiotic used to treat various bacterial infections in eye and eye disorders, including:
Read the Patient Information Leaflet if available from your pharmacist before you start taking Ciprofloxacin ophthalmic solution 1.25ml and each time you get a refill. If you have any questions, consult your doctor or pharmacist.
Ciprofloxacin ophthalmic solution 1.25ml can also be used for other purposes not listed in this medication guide.
Use Ciprofloxacin ophthalmic solution 1.25ml only as directed. Do not use it more often or for longer than prescribed. The concentration of the solution in the eye may be affected by other ingredients in the formulation, or by the preservative. For this reason, shake the bottle well before each use.
Ciprofloxacin ophthalmic solution 1.25ml should be used twice daily for the duration prescribed by your doctor. The dosage will depend on the type of eye infection you have and the severity of it. Follow the prescribed dosage instructions carefully. Do not change your dosage regimen or stop using this medicine without your doctor's approval.
Ciprofloxacin ophthalmic solution 1.25ml may also be used for other purposes beyond those listed. Please discuss any other medications you are taking with your doctor.
Common side effects:
More severe side effects may occur. Contact your doctor or pharmacist if you notice any unusual or severe side effects.
Serious side effects are rare but may occur. The most common are:
Serious side effects
This is not a complete list of all side effects that may occur. If you notice other effects not listed above, contact your doctor or pharmacist.
This document is for informational purposes only and should not be considered medical advice. This information does not constitute and should not rely solely on the expertise and experience of any physician.
Ciprofloxacin is a broad-spectrum antibiotic belonging to the fluoroquinolone class of medications. It is effective against many bacterial infections, including skin and soft tissue infections. Ciprofloxacin is commonly used to treat various bacterial infections, including urinary tract infections, respiratory tract infections, gonorrhea, urinary tract infections, and skin and soft tissue infections. It is important to note that ciprofloxacin should only be used under the guidance of a healthcare professional, and should only be prescribed by a specialist. Ciprofloxacin is effective against a wide range of bacteria.
Ciprofloxacin is used to treat infections caused by susceptible microorganisms such as:
Like all medications, Ciprofloxacin may cause side effects. Some of the most common side effects of Ciprofloxacin may include:
The usual dosage of Ciprofloxacin (Ciprofloxacin HCl) for adults is 1 gram twice daily for the first day and then 1 gram once daily for the next three days (every three months).
1. This study was the first to show that the ciprofloxacin mic values were similar to those of human subjects. 2. The ciprofloxacin mic values of patients with and without systemic lupus erythematosus (SLE) were comparable and the mic values of the patients were comparable, but the mic values of the patients with SLE were not. 3. The ciprofloxacin mic values of patients with systemic lupus erythematosus (SLE) were also comparable to those of patients without SLE. 4. The MIC values of ciprofloxacin and ciprofloxacin with SLE were lower than those of the patients with SLE. The MIC values of ciprofloxacin and ciprofloxacin with human subjects were similar and the MIC values of the patients with SLE were also similar. Conclusion: The ciprofloxacin mic values of SLE patients were comparable to those of patients without SLE. The MIC values of ciprofloxacin and ciprofloxacin with SLE were lower than those of the patients without SLE. Therefore, ciprofloxacin and ciprofloxacin with SLE are safe and effective in the treatment of SLE.
The ciprofloxacin mic values of patients with SLE were comparable to those of patients without SLE. The ciprofloxacin mic values of patients with SLE were also comparable to those of patients without SLE. 5. The ciprofloxacin mic values of SLE patients were also comparable to those of SLE patients. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28.Ciprofloxacin (Ciprofloxacin) is used in the treatment of severe infections in adults and children aged 2 years and above.
Ciprofloxacin is an antibiotic that belongs to the fluoroquinolone group of antibiotics. It works by killing or stopping the growth of bacteria. Ciprofloxacin belongs to the class of drugs called quinolone antibiotics. It is used to treat a wide range of infections, including those caused by bacterial infections. These infections include, but are not limited to, gonorrhea, acute bacterial sinusitis, pyelonephritis, and sepsis.
Ciprofloxacin is taken orally in the form of a tablet (Ciprofloxacin HCL) or a suspension (Ciprofloxacin) as a single dose. The usual starting dose of ciprofloxacin is one to three times daily. If symptoms do not improve after three days, the dose can be increased up to five times a day. It is important to complete the full course of the treatment even if you start feeling better, even if you feel better.
Ciprofloxacin (Ciprofloxacin) can cause side effects. The most common of which are:
The safety of using ciprofloxacin has not been established in children. However, you should not take ciprofloxacin if you are allergic to the ingredients contained in the tablets. Ciprofloxacin can cause allergic reactions in children.
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